An amplification system includes a differential output circuit that provides an amplified output to drive a load. A main amplifier is coupled to a terminal of the differential output circuit via a main path, corresponding to a transmission line. A peak amplifier is coupled to another terminal of the differential output circuit via a peak path, corresponding to a transmission line. In a single-ended mode while the peak amplifier is deactivated for amplification purposes, the peak path performs an impedance inversion to effectively ground the other terminal of the differential output circuit. In a differential mode, each of the peak amplifier and the main amplifier operates to conduct current to respective terminals of the differential output circuit and each of the main path and the peak path provides a predetermined output impedance to the differential output circuit.