Invention Grant
- Patent Title: Antibody-drug conjugates of tubulysin analogs with enhanced stability
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Application No.: US15587927Application Date: 2017-05-05
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Publication No.: US10279049B2Publication Date: 2019-05-07
- Inventor: Qiang Cong , Sanjeev Gangwar , Vangipuram S. Rangan , Mei-Chen Sung
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Yuan Chao
- Main IPC: A61K39/395
- IPC: A61K39/395 ; A61K47/68 ; C07K16/28
Abstract:
The drug component of an antibody-drug conjugate having a structure according to formula (II), where Ab, m, n, R1, R2, R3, R4, and R5 are as defined in the application, exhibits unexpectedly improved stability.
Public/Granted literature
- US20170326247A1 ANTIBODY-DRUG CONJUGATES OF TUBULYSIN ANALOGS WITH ENHANCED STABILITY Public/Granted day:2017-11-16
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