The present application belongs to the technical field of household commodity and provides a sterilization box applicable to sterilize cosmetic tools, which comprises a base assembly, a housing assembly connected to the base assembly and cooperating with the base assembly to form a first cavity, and a supporting assembly connected in the first cavity and being able to connect with a plurality of cosmetic tools. The base assembly is provided therein with a second cavity. The sterilization box further comprises a circulation assembly configured to drive air circulations in the first cavity and in the second cavity and a sterilization assembly configured to sterilize the cosmetic tools. The circulation assembly includes a first ventilation assembly cooperating with the second cavity and a second ventilation assembly cooperating with the first cavity. A heating assembly cooperating with the first ventilation assembly is connected in the second cavity.