The desalination system with mineral recovery is a system for desalinating water using spray drying, which allows for both the production of purified water and the recovery of mineral salts. The desalination system with mineral recovery is a two-stage system for zero-liquid discharge (ZLD) desalination of feed water. The feed water may be, for example, seawater, reverse osmosis (RO) brine (i.e., the waste brine from a RO process), nano-filtration (NF) reject, multistage flash (MSF) brine, or the like. The first stage receives the feed water and uses a spray drying process to produce concentrated brine and a first volume of purified water. The concentrated brine is fed to the second stage, which also uses a spray drying process to produce a second volume of purified water and a volume of recovered mineral salts.