Invention Grant
- Patent Title: Cell culture additives and their use for increased bioprotein production from cells
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Application No.: US15708389Application Date: 2017-09-19
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Publication No.: US10280217B2Publication Date: 2019-05-07
- Inventor: Jennifer Leonardi , Flavio Schwarz , Barbara Chiang , Alice Tseng
- Applicant: American Air Liquide Inc.
- Applicant Address: US CA Fremont
- Assignee: American Air Liquide, Inc.
- Current Assignee: American Air Liquide, Inc.
- Current Assignee Address: US CA Fremont
- Agent Allen E. White
- Main IPC: C12N5/07
- IPC: C12N5/07 ; C12N1/38 ; C07K16/18 ; C07K16/06
Abstract:
The invention relates to a method of increasing protein biomolecule production in which a) a cell that produces a heterologous protein biomolecule is cultured, and b) an Additive and/or a source of the Additive is added to the culture medium in an amount sufficient to (i) increase a total yield of the heterologous protein biomolecule secreted into the cell culture media and/or (ii) increase a specific cellular productivity of the heterologous protein biomolecule secreted into the cell culture media.
Public/Granted literature
- US20190085060A1 CELL CULTURE ADDITIVES AND THEIR USE FOR INCREASED BIOPROTEIN PRODUCTION FROM CELLS Public/Granted day:2019-03-21
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