Invention Grant
- Patent Title: Linkers and their application towards ADC
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Application No.: US15326386Application Date: 2015-07-13
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Publication No.: US10280229B2Publication Date: 2019-05-07
- Inventor: Chun Sing Li , Jian Li , Yong Cang , Shuhui Chen , Gang Li , Xiongbin Xu , Lun Lu
- Applicant: MEDSHINE DISCOVERY INC.
- Applicant Address: CN Jiangsu
- Assignee: MEDSHINE DISCOVERY INC.
- Current Assignee: MEDSHINE DISCOVERY INC.
- Current Assignee Address: CN Jiangsu
- Agency: Harness, Dickey & Pierce P.L.C.
- Priority: WOPCT/CN2014/082292 20140716
- International Application: PCT/CN2015/083840 WO 20150713
- International Announcement: WO2016/008392 WO 20160121
- Main IPC: A61K47/68
- IPC: A61K47/68 ; C07K16/30 ; C07K16/28 ; C07K19/00
Abstract:
The present invention relates to linkers, containing amide surrogates with a regular or a novel lysosomal enzymatic cleavable dipeptidic unit, to connect cytotoxic drugs to antibodies. The present invention also relates to ADCs (antibody-drug conjugates) derived from these amide surrogate linkers for the treatment of cancers.
Public/Granted literature
- US20170202974A1 LINKERS AND THEIR APPLICATION TOWARDS ADC Public/Granted day:2017-07-20
Information query
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