A lubricating oil composition and method of operating a boosted internal combustion engine. The lubricating oil composition has not more than 150 ppm sodium and includes a major amount of a base oil and an additive composition that includes one or more overbased calcium-containing detergents having a total base number of greater than 225 mg KOH/gram, in an amount sufficient to provide greater than 1100 ppm by weight to less than 2400 ppm by weight of calcium to the lubricating oil composition, and one or more molybdenum-containing compounds in an amount sufficient to provide at least about 80 ppm by weight molybdenum to the lubricating oil composition, all based on the total weight of the lubricating composition. The oil and method may reduce low-speed pre-ignition events in the boosted internal combustion engine relative to a number of low-speed pre-ignition events in the same engine lubricated with a reference lubricating oil.