Invention Grant
- Patent Title: Immune-compatible cells created by nuclease-mediated editing of genes encoding HLA
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Application No.: US15328628Application Date: 2015-08-06
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Publication No.: US10280402B2Publication Date: 2019-05-07
- Inventor: Jin Soo Kim , Dong Youn Hwang
- Applicant: College of Medicine Pochon CHA University Industry-Academic Cooperation Foundation , INSTITUTE FOR BASIC SCIENCE
- Applicant Address: KR Pocheon-si KR Daejeon
- Assignee: COLLEGE OF MEDICINE POCHON CHA UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION,INSTITUTE FOR BASIC SCIENCE
- Current Assignee: COLLEGE OF MEDICINE POCHON CHA UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION,INSTITUTE FOR BASIC SCIENCE
- Current Assignee Address: KR Pocheon-si KR Daejeon
- Agency: Lex IP Meister, PLLC
- Priority: KR10-2014-0101203 20140806
- International Application: PCT/KR2015/008267 WO 20150806
- International Announcement: WO2016/021972 WO 20160211
- Main IPC: C12N5/074
- IPC: C12N5/074 ; C12Q1/6881 ; C12N5/0735 ; C07K14/74 ; C12N5/073
Abstract:
The present invention relates to a method for producing immune-compatible cells or a cell population which comprises a step of editing one or two alleles of one or more immune-compatible antigen genes by gene deletion or modification in an isolated cell comprising at least one of the immune-compatible antigen genes selected from HLA (human leukocyte antigen)-A, HLA-B and HLA-DR, to immune-compatible cells produced by the method, and to a cell population comprising the immune-compatible cells produced by the method.
Public/Granted literature
- US20170327795A1 Immune-compatible cells created by nuclease-mediated editing of genes encoding HLA Public/Granted day:2017-11-16
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