Invention Grant
- Patent Title: Detection of unlabeled nucleic acids by changing solubility of surface-associating probes
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Application No.: US14540668Application Date: 2014-11-13
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Publication No.: US10280450B2Publication Date: 2019-05-07
- Inventor: Rastislav Levicky , Wanqiong Qiao , Yatao Liu
- Applicant: New York University
- Applicant Address: US NY New York
- Assignee: New York University
- Current Assignee: New York University
- Current Assignee Address: US NY New York
- Agency: Hodgson Russ LLP
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C12Q1/6816
Abstract:
Provided are methods and devices for detection of unlabeled nucleic acids. The detection methods are based on change of solubility of hydrophobic probes upon hybridization with a polynucleotide. In one embodiment, the probes are morpholino probes, having a fluorophore attached thereto. The morpholino probes are immobilized on a substrate that has fluorescence quenching functionality.
Public/Granted literature
- US20150141285A1 Detection of Unlabeled Nucleic Acids by Changing Solubility of Surface-Associating Probes Public/Granted day:2015-05-21
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