A method and apparatus for transmitting and receiving RF signals suitable for MRI and/or MRS from MR “coils” (antennae) that are arranged in an array next to a tissue-sample-slice holder that constrains the front, back, and edges of the tissue sample and is configured to rotate in a “roll” direction (about an axis parallel to the main DC magnetic field) and optionally also rotate in a pitch direction (at varying angles up and down, left-to-right, or both, relative to the roll axis and thus to the main DC magnetic field); the system optionally includes temperature control (heat and/or cooling), an optical grid that is marked or etched into a cover glass that holds the sample (in some embodiments, the grid is visible in the MRI images as well), an electrical and/or optical stimulation means for delivering stimulation Some embodiments combine optical image data with MR image data.