Systems and methods for implementing single-click ejection of a mountable device associated with a virtual machine. An example method comprises: receiving, by a guest agent running on a virtual machine managed by a virtual machine manager (VMM) of a host computer system, a device removal request from the VMM, the device removal request identifying a peripheral device to be unmounted by the virtual machine; causing, by the guest agent, a guest operating system (OS) of the virtual machine to unmount the peripheral device; receiving, by the guest agent, a notification of completion of a device unmounting operation performed by the virtual machine with respect to the peripheral device; and transmitting, by the guest agent to the VMM, an operation completion status identified by the notification.