Methods, systems, and computer-readable media for distributed transactions across multiple consensus groups are disclosed. A distributed transaction system comprises a proposer and a plurality of consensus groups, including a first consensus group comprising a first plurality of members and a second consensus group comprising a second plurality of members. The proposer proposes a transaction to at least a portion of the first consensus group and at least a portion of the second consensus group. A majority of the members in the first consensus group agree to perform the transaction, where the transaction is selected from a plurality of proposed transactions involving the first consensus group. A majority of the members in the second consensus group also agree to perform the transaction. The members of the first and second consensus groups perform the transaction to update a plurality of stored replicas.