A method improves a detection of a brain tissue pathology in magnetic resonance (MR) images of a patient. The method includes acquiring multiple MR imaging data for creating four different contrast maps of a patient brain. From the multiple MR imaging data, performing an estimation of gray matter (GM), white matter (WM) and cerebrospinal fluid (CSF) concentration for each voxel of a part of the patient brain. From the multiple MR imaging data, segmenting the part of the patient brain in different regions-of-interest (ROIs) according to a chosen atlas. For each voxel of each of the contrast maps of the patient brain, computing, for the part of the patient brain, a deviation score. The method further includes creating from the deviation score and for each of the quantitative contrast maps, a deviation map representing the part of the brain in dependence on the deviation score calculated for each voxel.