A neuromorphic synapse with a resistive memory cell connected in circuitry having first and second input terminals. The input terminals respectively receive pre-neuron and post-neuron action signals, each having a read portion and a write portion, in use. The circuitry includes an output terminal for providing a synaptic output signal which is dependent on resistance of the memory cell. The circuitry is configured such that the synaptic output signal is provided at the output terminal in response to application at the first input terminal of the read portion of the pre-neuron action signal, and such that a programming signal, for programming resistance of the memory cell, is applied to the cell in response to simultaneous application of the write portions of the pre-neuron and post-neuron action signals at the first and second input terminals respectively. The synapse can be adapted for operation with identical pre-neuron and post-neuron action signals.