A system and method are provided for interactive editing of a mesh which has been applied to a three-dimensional (3D) image to segment an anatomical structure shown therein. To facilitate the interactive editing of the applied mesh, a view of the 3D image is generated which shows a mesh part to be edited, with the view being established based on a local orientation of the mesh part. Advantageously, the view may be generated to be substantially orthogonally to the mesh part, or to a centerline of the anatomical structure which is determined as a function of the mesh part. Accordingly, an orthogonal view is established which facilitates the user in carrying out the editing action with respect to the mesh part. It is therefore not needed for the user to manually navigate through the 3D image to obtain a view which is suitable for mesh editing, which is typically time consuming.