Systems and methods for enhancing reverberated audio signals are disclosed. In one embodiment, a method is disclosed comprising receiving an audio signal; partitioning a frequency domain representation of the audio signal into a plurality of sub-band vectors; inputting each sub-band vector into a corresponding deep neural network; calculating, using the corresponding deep neural networks, a plurality of output vectors for each sub-band; concatenating the plurality of output vectors to generate a clean audio feature matrix; and converting the clean audio feature matrix into a time-domain audio signal.