Disclosed are a D2D communication method and device. The method comprises: sending a. preamble on a sub-channel set of a competition region, and monitoring the preamble on the sub-channel set of the competition region; and if the preamble is not monitored on the sub-channel set of the competition region, sending data on a sub-channel set of a data region corresponding to the sub-channel set of the competition region, different sub-channel sets of the competition region corresponding to different sub-channel sets of the data region. The technical solution provided in the embodiments of the present invention can effectively avoid the resource conflict of a D2D UE. In addition, since a preamble occupies fewer resources, competing for sub-channel resources of a data region by sending a preamble could effectively reduce the overhead of resource competition.