An electronic device with anti-disassembly structure includes a top cover having a first set of serrated teeth and a first through hole, a fastener receiver having a posting head and a posting body, a fixed disk having a fourth set of serrated teeth, an elastic member, a bottom cover having a second through hole, and a fastener. The posting head has a second set of serrated teeth and a third set of serrated teeth. When the top cover is separated from the bottom cover, the elastic member is compressed by the external force, and the second set of serrated teeth is separated with the first set of serrated teeth, the third set of serrated teeth engage with the fourth set of serrated teeth, and the fastener is rotated to detached from the bottom cover.