A system and method of repositioning a region of interest within an endoscopic image from a first location to a target location on the display screen of an endoscopy system is provided. The endoscopy system includes an insertion portion having a tip section with at least one viewing element for capturing images of a body cavity having the region of interest. The method includes detecting a region of interest within a body cavity, displaying the region of interest on a display screen in communication with the endoscopy system, marking the region of interest on the display screen, selecting a target location on the display screen, estimating a transformation to be applied to the region of interest, and applying the estimated transformation for causing the region of interest to be displayed at the target location of the display screen.