The present invention discloses a multifunctional critical care system and an operation method thereof. A lifting frame disposed on the bed body, a bed plate and a plurality of lifting bands are disposed at the lifting frame, and a tensioning mechanism is disposed on the lifting frame; The bed plate comprises vertical elevating mechanisms, a transverse telescopic mechanism disposed between the vertical elevating mechanisms; the lifting frame is connected to a tilting mechanism; fastening the lifting bands to lifting bands fastening devices, actuating the vertical elevating power mechanisms; actuating the transverse telescopic power mechanism; actuating the tensioning power mechanism; and actuating the transmission power mechanism. The nursing care mechanism facilitates replacement of bed sheets, ventilating the back, letting the patient laid on their left or right side, cleaning and wiping the body, defecation; and combines the functions of a nursing equipment, a sickbed, and a wheelchair.