- Patent Title: Substituted polycyclic pyridone derivatives and prodrugs thereof
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Application No.: US15569191Application Date: 2016-04-27
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Publication No.: US10294241B2Publication Date: 2019-05-21
- Inventor: Makoto Kawai
- Applicant: Shionogi & Co., Ltd.
- Applicant Address: JP Osaka
- Assignee: SHIONOGI & CO., LTD.
- Current Assignee: SHIONOGI & CO., LTD.
- Current Assignee Address: JP Osaka
- Agency: Wenderoth, Lind & Ponack, L.L.P.
- Priority: JP2015-090909 20150428; JP2015-236844 20151203
- International Application: PCT/JP2016/063139 WO 20160427
- International Announcement: WO2016/175224 WO 20160311
- Main IPC: C07D471/14
- IPC: C07D471/14 ; C07D498/14 ; A61K31/53 ; A61K31/5383 ; A61K31/542 ; A61K31/553 ; A61K31/675 ; C07F9/6561 ; C07D471/20 ; C07D491/22 ; C07D513/14 ; A61P31/16 ; C07D519/00 ; C07F7/18

Abstract:
The present invention provides the following compounds having anti-viral activity. A1 is CR1AR1B, S or O; A2 is CR2AR2B, S or O; A3 is CR3AR3B, S or O; A4 is CR4AR4B, S or O; the number of hetero atoms among atoms constituting the ring which consists of A1, A2, A3, A4, nitrogen atom adjacent to A1 and carbon atom adjacent to A1, is 1 or 2; R1A and R1B are each independently hydrogen, halogen, alkyl, or the like; R2A and R2B are each independently hydrogen, halogen, alkyl, or the like; R3A and R3B are each independently hydrogen, halogen, alkyl, or the like; R4A and R4B are each independently hydrogen, halogen, alkyl, or the like; R3A and R3B may be taken together to form non-aromatic carbocycle or non-aromatic heterocycle; X is CH2, S or O; R1 is each independently halogen, hydroxy, or the like; m is any integer of 0 to 2; and n is any integer of 1 to 2.
Public/Granted literature
- US10392406B2 Substituted polycyclic pyridone derivatives and prodrugs thereof Public/Granted day:2019-08-27
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