- Patent Title: Method of isolating aptamers for minimal residual disease detection
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Application No.: US15414376Application Date: 2017-01-24
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Publication No.: US10294471B2Publication Date: 2019-05-21
- Inventor: Qiao Lin , Milan N. Stojanovic , Timothy R. Olsen , Tilla S. Worgall
- Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Applicant Address: US NY New York
- Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee Address: US NY New York
- Agency: Baker Botts L.L.P.
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12N15/10 ; C12N15/115
Abstract:
A method for selecting and isolating aptamers that target M-Ig proteins with a microdevice including at least a first selection chamber is provided. The method includes preparing a first sample of M-Ig proteins from a serum; placing the M-Ig proteins in the first selection chamber; introducing a first group of oligomers including at least an M-Ig targeting oligomer into the first selection chamber, whereby the M-Ig targeting oligomer binds to the first sample of M-Ig proteins. The method further includes removing unbound oligomers of the first sample from the first selection chamber to isolate the M-Ig targeting oligomer.
Public/Granted literature
- US20170130218A1 METHOD OF ISOLATING APTAMERS FOR MINIMAL RESIDUAL DISEASE DETECTION Public/Granted day:2017-05-11
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