Invention Grant
- Patent Title: Aptamer modulators of estrogen receptors
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Application No.: US14239012Application Date: 2012-08-16
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Publication No.: US10294478B2Publication Date: 2019-05-21
- Inventor: Hua Shi , Daiying Xu , Vamsee Krishna Chatakonda
- Applicant: Hua Shi , Daiying Xu , Vamsee Krishna Chatakonda
- Applicant Address: US NY Albany
- Assignee: The Research Foundation for The State University of New York
- Current Assignee: The Research Foundation for The State University of New York
- Current Assignee Address: US NY Albany
- Agency: Pepper Hamilton LLP
- International Application: PCT/US2012/051197 WO 20120816
- International Announcement: WO2013/025930 WO 20130221
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C12N15/115 ; C07K14/72
Abstract:
The present invention relates to a nucleic acid aptamer molecule that includes a domain that binds to an estrogen receptor, molecular complexes that include the nucleic acid aptamer molecule and an estrogen receptor, and constructed DMA molecules and expression systems, as well as host cells, that the contain an RNA aptamer molecule of the invention. Use of these aptamers and encoding constructs to inhibiting estrogen receptor activity in a cell and to treat estrogen receptor-positive cancers is also described.
Public/Granted literature
- US20150031754A1 APTAMER MODULATORS OF ESTROGEN RECEPTORS Public/Granted day:2015-01-29
Information query
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