A turbo-compression cooling system includes a power cycle and a cooling cycle coupled one to the other. The power cycle implements a waste heat waste heat exchanger configured to evaporate a first working fluid and a turbine configured to receive the evaporated working fluid. The turbine is configured to rotate as the first working fluid expands to a lower pressure. A condenser condenses the first working fluid to a saturated liquid and a pump pumps the saturated liquid to the waste heat waste heat exchanger. The cooling cycle implements a compressor increasing the pressure of a second working fluid, a condenser condensing the second working fluid to a saturated liquid upon exiting the compressor, an expansion valve expanding the second working fluid to a lower pressure, and an evaporator rejecting heat from a circulating fluid to the second working fluid, thereby cooling the circulating fluid.