The present invention describes a method for magnetic resonance (MR) and/or MR imaging, comprising acquisition of signals and MR images originating from a RE and gradient sequence causing isotropic diffusion weighting of signal attenuation, wherein the isotropic diffusion weighting is achieved by one time-dependent dephasing vector q(t) having an orientation, wherein the isotropic diffusion weighting is proportional to the trace of a diffusion tensor D, and wherein the orientation of the time-dependent dephasing vector q(t) is either varied discretely in more than three directions in total, or changed continuously, or changed in a combination of discretely and continuously during the gradient pulse sequence, 0≤t≤echo time, where t represents the time. The method may be performed during a single shot (single MR excitation).