Embodiments of a multi-form factor Information Handling System (IHS) with a removable keyboard are described. In an illustrative, non-limiting embodiment, an IHS may include a processor and a memory coupled to the processor, the memory having program instructions stored thereon that, upon execution by the processor, cause the IHS to: identify a physical arrangement of: (i) a first display, (ii) a second display coupled to the first display, and (iii) a keyboard; and execute an operation associated with the physical arrangement.