A system and method includes reception of an indication of a region of interest of a plurality of image frames, determination of a first set of pixel locations of the region of interest which depict blood vessels, determination of a second set of pixel locations of the region of interest which depict non-vessel tissue, determination, for each of the plurality of the image frames, of a first contrast medium concentration corresponding to the first set of pixel locations, determination, for each of the plurality of the image frames, of a second contrast medium concentration corresponding to the second set of pixel locations, and display of a visualization depicting a first contrast medium concentration and a second medium concentration with respect to the respective time of each of the plurality of the image frames.