A method of protecting a serializer/deserializer (SERDES) differential input/output (I/O) circuit includes detecting an electrostatic discharge event. The method also includes selectively disengaging a power supply terminal from a pair of I/O transistors of the SERDES differential I/O circuit in response to the detected electrostatic discharge event. The method further includes selectively disengaging a ground terminal from the pair of I/O transistors of the SERDES differential I/O circuit in response to the detected electrostatic discharge event.