Mechanisms for spatially isolating a region of interest (ROI) in a scene. A first sensor generates sensor data that quantifies energy received from a scene within a field of view (FOV) of the first sensor to generate a real-time FOV full motion video. A processor analyzes the sensor data to identify a first ROI during a wait period of a frame period of the first sensor. A first subset of micromirrors in a micromirror array that is directed toward the scene is identified. The first subset of micromirrors receives energy from the first ROI. A micromirror in the first subset is controlled to move from a primary position of the at least one micromirror to a first tilt position of the micromirror to reflect the energy from the first ROI toward a second sensor, the first ROI being spatially isolated from the real-time FOV full motion video.