The present technology relates to an image processing device, image processing method, electronic apparatus, and program, capable of performing motion detection allowing the effects by periodic noise such as flicker to be reduced. An image processing device includes an intensity ratio calculation unit configured to calculate a ratio relating to an intensity of a signal value at a predetermined position in an image captured under different exposure conditions, and a contribution calculation unit configured to calculate a contribution indicating whether an intensity ratio calculated by the intensity ratio calculation unit is derived from a periodic noise component or is derived from motion. The periodic noise is, for example, flicker. The intensity ratio calculation unit calculates the intensity ratio from one image captured using an image sensor in which pixels for which the different exposure conditions are set exist together. The present technology is applicable to an imaging device.