Invention Grant
- Patent Title: Drug delivery formulation for controlling of initial burst and manufacturing method thereof
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Application No.: US13022734Application Date: 2011-02-08
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Publication No.: US10307373B2Publication Date: 2019-06-04
- Inventor: Moon Suk Kim , Da Yeon Kim
- Applicant: Moon Suk Kim , Da Yeon Kim
- Applicant Address: KR Suwon-si
- Assignee: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
- Current Assignee: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
- Current Assignee Address: KR Suwon-si
- Agency: Vorys, Sater, Seymour & Pease LLP
- Agent Mih Suhn Koh
- Priority: KR10-2011-0003271 20110112
- Main IPC: A61K9/10
- IPC: A61K9/10 ; A61K9/00 ; A61K9/16 ; A61K9/50 ; A61K47/34 ; A61K38/00

Abstract:
Provided is a drug delivery system for control of initial burst of a drug. More particularly, there are provided a drug delivery formulation including: a granule containing a biodegradable polymer and a drug; and a temperature-sensitive hydrogel, and a method for preparing the same. The presently disclosed drug delivery formulation can be prepared via a relatively simple process and allows a drug to be released slowly at a constant rate without initial burst and thus maintains a constant blood level of the drug for a long period of time. Consequently, it is capable of preventing the initial burst of the existing injection-type drug delivery formulations and slow-release granules and providing a desired release profile, including sustained release with time.
Public/Granted literature
- US20120177740A1 DRUG DELIVERY FORMULATION FOR CONTROLLING OF INITIAL BURST AND MANUFACTURING METHOD THEREOF Public/Granted day:2012-07-12
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