Invention Grant
- Patent Title: Tetrahydro- and dihydro-isoquinoline PRMT5 inhibitors and uses thereof
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Application No.: US15419260Application Date: 2017-01-30
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Publication No.: US10307413B2Publication Date: 2019-06-04
- Inventor: Kenneth W. Duncan , Richard Chesworth , Paula Ann Boriack-Sjodin , Michael John Munchhof , Lei Jin
- Applicant: Epizyme, Inc.
- Applicant Address: US MA Cambridge
- Assignee: Epizyme, Inc.
- Current Assignee: Epizyme, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Wolf, Greenfield & Sacks, P.C.
- Main IPC: A61K31/506
- IPC: A61K31/506 ; A61K31/4725 ; C07D401/14 ; C07D217/12 ; C07D401/12 ; C07D405/12 ; C07D217/04 ; C07D405/14 ; C07D413/12 ; C12N9/10 ; A61P7/06 ; A61P3/04 ; A61P3/10 ; A61P35/00 ; A61K31/496 ; A61K31/498 ; A61K31/5377 ; A61K31/538
Abstract:
Described herein are compounds of Formula (A), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5-mediated disorders are also described.
Public/Granted literature
- US20170334861A1 TETRAHYDRO- AND DIHYDRO-ISOQUINOLINE PRMT5 INHIBITORS AND USES THEREOF Public/Granted day:2017-11-23
Information query
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