Invention Grant
- Patent Title: Coupling method for peptide synthesis at elevated temperatures
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Application No.: US14969004Application Date: 2015-12-15
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Publication No.: US10308677B2Publication Date: 2019-06-04
- Inventor: Jonathan M. Collins , Sandeep Kumar Singh
- Applicant: CEM CORPORATION
- Applicant Address: US NC Matthews
- Assignee: CEM Corporation
- Current Assignee: CEM Corporation
- Current Assignee Address: US NC Matthews
- Agency: Summa PLLC
- Main IPC: C07K1/10
- IPC: C07K1/10 ; C07K14/575 ; C07K1/04 ; C07K1/08
Abstract:
An improved method for coupling carboxylic acids and amines is disclosed that includes the steps of combining a hyper-acid sensitive linker connecting an amine and a resin, a carboxylic acid, a carbodiimide, an activator additive, and a base, and carrying out the activation and coupling at a temperature greater than 30° C.
Public/Granted literature
- US20160176918A1 COUPLING METHOD FOR PEPTIDE SYNTHESIS AT ELEVATED TEMPERATURES Public/Granted day:2016-06-23
Information query
