- Patent Title: Pharmaceutical composition for the prevention and treatment of cardiovascular disease comprising the peptide having the ability to inhibit angiotensin-1 converting enzyme as an active ingredient
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Application No.: US15856926Application Date: 2017-12-28
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Publication No.: US10308681B2Publication Date: 2019-06-04
- Inventor: Se-Young Choung , Yeung Joon Choi
- Applicant: University-Industry Cooperation Group of Kyung Hee University , Industry-Academic Cooperation Foundation Gyeongsang National University
- Applicant Address: KR Yongin-si, Gyeonggi-Do KR Jingu-si, Gyeongsangnam-Do
- Assignee: UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY,INDUSTRY-ACADEMIC COOPERATION FOUNDATION GYEONGSANG NATIONAL UNIVERSITY
- Current Assignee: UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY,INDUSTRY-ACADEMIC COOPERATION FOUNDATION GYEONGSANG NATIONAL UNIVERSITY
- Current Assignee Address: KR Yongin-si, Gyeonggi-Do KR Jingu-si, Gyeongsangnam-Do
- Agency: Lucas & Mercanti, LLP
- Priority: KR10-2012-0092738 20120824; KR10-2013-0100232 20130823
- Main IPC: C07K5/062
- IPC: C07K5/062 ; C07K5/078 ; C07K5/068 ; C07K5/083 ; C07K5/097 ; C07K5/087 ; C07K5/065
Abstract:
The present invention relates to a peptide separated from the fraction of oyster enzyme hydrolysate displaying the ability of suppressing angiotensin converting enzyme (ACE) and a pharmaceutical composition for the prevention and treatment of cardiovascular disease comprising the said peptide as an active ingredient. Particularly, the peptide separated from the fraction of the oyster enzyme hydrolysate of the present invention significantly inhibits ACE activity, and thus brings blood pressure regulating effect and antihypertensive effect. Therefore, the fraction of the oyster enzyme hydrolysate of the invention or the peptide separated from the same can be effectively used as an active ingredient of a pharmaceutical composition for the prevention or treatment of cardiovascular disease.
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