Invention Grant
- Patent Title: Optimized human clotting factor VIII gene expression cassettes and their use
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Application No.: US15017015Application Date: 2016-02-05
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Publication No.: US10308705B2Publication Date: 2019-06-04
- Inventor: Xiao Xiao , Juan Li , Zhenhua Yuan
- Applicant: The University of North Carolina at Chapel Hill
- Applicant Address: US NC Chapel Hill
- Assignee: The University of North Carolina at Chapel Hill
- Current Assignee: The University of North Carolina at Chapel Hill
- Current Assignee Address: US NC Chapel Hill
- Agency: Myers Bigel, P.A.
- Main IPC: C07K14/755
- IPC: C07K14/755 ; C12N15/63 ; A61K38/00
Abstract:
The invention relates to synthetic liver-specific promoters and expression constructs for producing polypeptides and functional nucleic acids in the liver of a subject. The invention further relates to Factor VIII proteins containing modifications in the amino acid sequence of the Factor VIII protein, as well as nucleic acid constructs encoding the Factor VIII proteins and methods of using these compositions to treat a bleeding disorder.
Public/Granted literature
- US20160229904A1 Optimized Human Clotting Factor VIII Gene Expression Cassettes and Their Use Public/Granted day:2016-08-11
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