Invention Grant
- Patent Title: Methods to accelerate antibody diversification
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Application No.: US15514052Application Date: 2015-11-05
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Publication No.: US10308930B2Publication Date: 2019-06-04
- Inventor: Xiaohua Wang , Matthew Scharff
- Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.
- Applicant Address: US NY Bronx
- Assignee: Albert Einstein College of Medicine
- Current Assignee: Albert Einstein College of Medicine
- Current Assignee Address: US NY Bronx
- Agency: Amster, Rothstein & Ebenstein LLP
- International Application: PCT/US2015/059130 WO 20151105
- International Announcement: WO2016/073660 WO 20160512
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C07H21/02 ; C07H21/04 ; C12N15/10 ; C07K16/00 ; C07K14/005 ; C12N9/78 ; C12N15/113 ; C12N15/86
Abstract:
Methods for increasing somatic hypermutation of antibodies, especially in vitro expression of an isolated retroviral protein in an isolated mammalian immunoglobulin-producing cell, are provided.
Public/Granted literature
- US20180179516A1 METHODS TO ACCELERATE ANTIBODY DIVERSIFICATION Public/Granted day:2018-06-28
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