Invention Grant
- Patent Title: Methods for triggering de novo formation of heterochromatin and or epigenetic silencing with small RNAS
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Application No.: US15321159Application Date: 2015-06-22
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Publication No.: US10308935B2Publication Date: 2019-06-04
- Inventor: Marc Buehler , Katarzyna Kowalik , Yukiko Shimada
- Applicant: Marc Buehler , Katarzyna Kowalik , Yukiko Shimada
- Applicant Address: CH Basel
- Assignee: FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH
- Current Assignee: FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH
- Current Assignee Address: CH Basel
- Agency: Hoxie & Associates LLC
- Priority: EP14173523 20140623
- International Application: PCT/IB2015/054665 WO 20150622
- International Announcement: WO2015/198202 WO 20151230
- Main IPC: C12N15/85
- IPC: C12N15/85 ; C12N15/113 ; A61K31/7105 ; C12N15/82
Abstract:
The present application relates to a method for the targeted formation of heterochromatin and/or induction of epigenetic gene silencing in a cell using a small RNA, said method comprising the step of inhibiting the Paf1 complex in said cell and the step of contacting said cell with a small RNA targeted to a region of the genome of the cell, said region being the region where heterochromatin formation and/or induction of epigenetic gene silencing should be induced.
Public/Granted literature
- US20170152514A1 METHODS FOR TRIGGERING DE NOVO FORMATION OF HETEROCHROMATIN AND OR EPIGENETIC SILENCING WITH SMALL RNAS Public/Granted day:2017-06-01
Information query
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