Invention Grant
- Patent Title: Nucleic acids encoding engineered imine reductases
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Application No.: US16195480Application Date: 2018-11-19
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Publication No.: US10308966B2Publication Date: 2019-06-04
- Inventor: Haibin Chen , Steven J. Collier , Jovana Nazor , Joly Sukumaran , Derek Smith , Jeffrey C. Moore , Gregory Hughes , Jacob Janey , Gjalt W. Huisman , Scott J. Novick , Nicholas J. Agard , Oscar Alvizo , Gregory A. Cope , Wan Lin Yeo , Stefanie Ng Minor
- Applicant: CODEXIS, INC.
- Applicant Address: US CA Redwood City
- Assignee: Codexis, Inc.
- Current Assignee: Codexis, Inc.
- Current Assignee Address: US CA Redwood City
- Agency: Codexis, Inc.
- Main IPC: C12N9/06
- IPC: C12N9/06 ; C12P13/00 ; C12P13/02 ; C12P13/04 ; C12P13/06 ; C12P17/10 ; C12P17/12 ; C12P17/16 ; C12P17/18
Abstract:
The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
Public/Granted literature
- US20190078124A1 ENGINEERED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS Public/Granted day:2019-03-14
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