Invention Grant
- Patent Title: Methods for controlling fucosylation levels in proteins
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Application No.: US15819351Application Date: 2017-11-21
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Publication No.: US10308970B2Publication Date: 2019-06-04
- Inventor: Pradip Nair , Ramakrishnan Melarkode , Rasika Venkataraman , Laxmi Adhikary , Ankur Bhatnagar , Sunaina Prabhu , Kriti Shukla , Dinesh Baskar , Saravanan Desan , Harish Venkatraman Pai , Jose Enrique Montero Casimiro
- Applicant: BIOCON LIMITED
- Applicant Address: IN
- Assignee: BIOCON LIMITED
- Current Assignee: BIOCON LIMITED
- Current Assignee Address: IN
- Agency: Olive Law Group, PLLC
- Agent Marianne Fuierer
- Priority: IN3262/CHE/2013 20130723; IN3265/CHE/2013 20130723
- Main IPC: A61K39/00
- IPC: A61K39/00 ; C07K16/00 ; C07K16/28 ; C12P21/00
Abstract:
The present invention relates to a method or process for controlling, inhibiting or reducing protein fucosylation in a eukaryote and/or eukaryotic protein expression system. Said method comprises carrying out the protein expression and/or post-translational modification in the presence of an elevated total concentration of manganese or manganese ions.
Public/Granted literature
- US20180087080A1 METHODS FOR CONTROLLING FUCOSYLATION LEVELS IN PROTEINS Public/Granted day:2018-03-29
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