Invention Grant
- Patent Title: Device and method for processing a biological sample and analysis system for analyzing a biological specimen
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Application No.: US15311142Application Date: 2015-04-29
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Publication No.: US10308977B2Publication Date: 2019-06-04
- Inventor: Thomas Brettschneider , Jochen Hoffmann , Karin Lemuth
- Applicant: Robert Bosch GmbH
- Applicant Address: DE Stuttgart
- Assignee: Robert Bosch GmbH
- Current Assignee: Robert Bosch GmbH
- Current Assignee Address: DE Stuttgart
- Agency: Maginot, Moore & Beck LLP
- Priority: DE102014209188 20140515
- International Application: PCT/EP2015/059265 WO 20150429
- International Announcement: WO2015/173016 WO 20151119
- Main IPC: G01N21/00
- IPC: G01N21/00 ; C12Q1/6806 ; C12N1/06 ; C12N13/00 ; B01L3/00 ; C12N15/10 ; G01N1/40

Abstract:
A device for processing a biological sample includes a first substrate having a first cavity, a second substrate having a second cavity, a filter element having a plurality of perforations, and an electrically conductive structure. The first cavity forms a first chamber segment of a chamber for accommodating the biological sample. The second cavity forms a second chamber segment of the chamber for accommodating the biological sample. The filter element is formed between the first cavity and the second cavity in order to hold back a plurality of organic cells of the biological sample on the plurality of perforations when the biological sample moves between the first cavity and the second cavity through the filter element. The electrically conductive structure is arranged on the filter element and is configured to cause lysis of the organic cells and/or to duplicate and/or detect defined segments of exposed DNA.
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