The present invention discloses a mobile health intelligent medical guide system and method thereof. The method comprises: collecting patient chief complaint by use of a mobile terminal, sending the patient chief complaint to a cloud server through the mobile phone device internet, analyzing and processing the patient chief complaint by use of the keyword extraction, text word segmentation, fuzzy matching and sorting recommendation technologies based on a medical knowledge base, automatically generating a disease examination result, and generating an intelligent medical guide result to be fed back to the mobile terminal in combination with the doctor information; and then optimizing the disease examination result and the intelligent medical guide result one by one until the patient ends the query or the diagnosis result achieves the optimum. The system can assist the patient to perform self-helped disease examination and medical guide in the mobile environment.