A mobile information handling system executing code instructions of a dynamic antenna co-existence control system may comprise a plurality of transceiving antennas mounted in a small form factor case for the mobile information handling system, a plurality of cellular and Wi-Fi communications modules transceiving signals according to a plurality of data streams, an adaptive massive MIMO multiplexer coupling the communications modules to the four transceiving antennas, a memory storing a data stream multiplexing configuration table, and a processor. The processor may execute code instructions of the dynamic antenna coexistence control system to receive trigger inputs describing an operational condition of the mobile information handling system, identify one or more of the plurality of configurations of the plurality of data streams as an optimal configuration for enhancing throughput based on the trigger inputs, and instruct the adaptive massive MIMO multiplexer to operate according to the optimal configuration.