Methods and systems for performing load balancing and session persistence in IP (e.g., IPv6) networks are described herein. Some aspects relate to a destination options extension header that may be used to store load balancing session persistence option (LBSPO) data, including a client identifier and a server identifier for each of a client and a server. A load balancer for a server farm can perform session persistence and load balancing based on the LBSPO information. The server can include its own address in the LBSPO data when responding to an initial request from a client. The client device may then address subsequent packets to the server selected for that session, thereby bypassing the load balancer after the session is established, thereby freeing the load balancer to handle other requests. The LBSPO information may remain unchanged for the duration of the session.