Operation of a multi-slice processor that includes a plurality of execution slices. Operation of such a multi-slice processor includes: receiving a first instruction indicating a first target register; receiving a second instruction indicating the first target register as a source operand; responsive to the second instruction indicating the first target register as a source operand, updating a dependent count corresponding to the first instruction; and issuing, in dependence upon the dependent count for the first instruction being greater than a dependent count for another instruction, the first instruction to an execution slice of the plurality of execution slices.