Embodiments of the present disclosure provide a pulse generation device, an array substrate, a drive circuit and a driving method. The pulse generation device includes: a reset module making a pulse output end output low level, in response to a low level of a first input end or in response to a low level of a second input end and a low level of a third input end; a pulse generation module making the pulse output end output a high level, in response to a high level of the first input end, a high level of the second input end and a low level of the third input end or in response to a high level of the first input end, a low level of the second input end and a high level of the third input end.