A cutting board with removable drip pan system includes at least one drip pan and a cutting board. The cutting board includes a top surface, a bottom surface, a front edge, a back edge, and a pair of opposing sides, and is constructed from materials suitable for direct contact with food. A pair of guides is positioned along the bottom surface of the cutting board to receive the edges of the drip pan. A plurality of channels each having at least one aperture are positioned along the top surface to direct liquids from the top surface into the drip pan.