Invention Grant
- Patent Title: Administration of ubiquitin-activating enzyme inhibitor and radiation
-
Application No.: US15522717Application Date: 2015-10-23
-
Publication No.: US10335411B2Publication Date: 2019-07-02
- Inventor: Neil Bence , Marc Hyer , Michael Milhollen , Vivek Samnotra , Sergio Luis Santillana Soto , Darshan Sappal
- Applicant: Millennium Pharmaceuticals, Inc.
- Applicant Address: US MA Cambridge
- Assignee: Millennium Pharmaceuticals, Inc.
- Current Assignee: Millennium Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Sterne, Kessler, Goldstein & Fox P.L.L.C.
- International Application: PCT/US2015/057064 WO 20151023
- International Announcement: WO2016/069393 WO 20160506
- Main IPC: A61N5/10
- IPC: A61N5/10 ; A61K41/00 ; A61P35/00 ; A61K31/519
Abstract:
Disclosed are methods for the treatment of cancer in patients in need of such treatment. The methods comprise administering to such a patient an ubiquitin-activating enzyme (UAE) inhibitor such as ((1R,2R,3S,4R)-2,3-dihydroxy-4-(2-(3-(trifluoromethylthio) phenyl)pyrazolo[1,5-a]pyrimidin-7-ylamino)cyclopentyl)methyl sulfamate (Compound 1) or a pharmaceutically acceptable salt in combination with radiation. Also disclosed are medicaments for use in the treatment of cancer.
Public/Granted literature
- US20170333434A1 ADMINISTRATION OF UBIQUITIN-ACTIVATING ENZYME INHIBITOR AND RADIATION Public/Granted day:2017-11-23
Information query
