Invention Grant
- Patent Title: Hydrogel precursors having nanoparticles
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Application No.: US14918229Application Date: 2015-10-20
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Publication No.: US10335515B2Publication Date: 2019-07-02
- Inventor: Michael Detamore , Emily Beck , Stevin Gehrke , Cory Berkland
- Applicant: The University of Kansas
- Applicant Address: US KS Lawrence
- Assignee: The University of Kansas
- Current Assignee: The University of Kansas
- Current Assignee Address: US KS Lawrence
- Agency: Maschoff Brennan
- Main IPC: A61L27/48
- IPC: A61L27/48 ; A61L27/52 ; A61L27/54 ; A61L27/20 ; A61L27/38 ; A61L27/50

Abstract:
An implantable hydrogel precursor composition can include: a cross-linkable polymer matrix that is biocompatible; and a plurality of polymer particles in the cross-linkable polymer matrix. The cross-linkable polymer matrix can include a cross-linkable hyaluronic acid polymer that has cross-linkable functional groups. The hyaluronic acid polymer can be a methacrylated hyaluronic acid polymer. The methacrylated hyaluronic acid polymer can have a molecular weight from about 500 kDa to about 1.8 MDa. The polymer particles can include a cross-linked hyaluronic acid. The cross-linkable polymer matrix having the polymer particles has a yield stress. The cross-linkable polymer matrix having the polymer particles has shape retention at physiological temperatures. The composition can include live cells in the cross-linkable polymer matrix. The composition can include a biologically active agent in the cross-linkable polymer matrix.
Public/Granted literature
- US20160038643A1 HYDROGEL PRECURSORS HAVING NANOPARTICLES Public/Granted day:2016-02-11
Information query
IPC分类: