Invention Grant
- Patent Title: Substituted glycine derived FXIA inhibitors
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Application No.: US15750212Application Date: 2016-08-03
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Publication No.: US10336730B2Publication Date: 2019-07-02
- Inventor: James R. Corte , William R. Ewing , Donald J. P. Pinto , Leon M. Smith, II
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agency: Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
- International Application: PCT/US2016/045276 WO 20160803
- International Announcement: WO2017/023992 WO 20170209
- Main IPC: C07D403/10
- IPC: C07D403/10 ; C07D401/14 ; C07D405/14 ; C07D413/14 ; C07D401/10 ; C07D237/14 ; C07D403/14 ; C07D417/14 ; C07D471/04 ; C07D471/08 ; C07D471/10 ; C07D487/04 ; A61P7/02 ; C07D211/86 ; C07D409/14 ; C07D498/04

Abstract:
The present invention provides compounds of Formula (I): (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
Public/Granted literature
- US20180222889A1 NOVEL SUBSTITUTED GLYCINE DERIVED FXIA INHIBITORS Public/Granted day:2018-08-09
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