Invention Grant
- Patent Title: Substituted 1H-indole-2-carboxamide compounds as indoleamine-2,3-dioxygenase inhibitors
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Application No.: US15760697Application Date: 2016-09-12
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Publication No.: US10336731B2Publication Date: 2019-07-02
- Inventor: Phillip M. Cowley , Yongxin Han
- Applicant: Merck Sharp & Dohme Corp. , IOmet Pharma Ltd.
- Applicant Address: US NJ Rahway GB
- Assignee: Merck Sharp & Dohme Corp.,Iomet Pharma Ltd.
- Current Assignee: Merck Sharp & Dohme Corp.,Iomet Pharma Ltd.
- Current Assignee Address: US NJ Rahway GB
- Agent Yong Zhao; Catherine D. Fitch
- Priority: GB1516411.4 20150916
- International Application: PCT/US2016/051221 WO 20160912
- International Announcement: WO2017/048612 WO 20170323
- Main IPC: C07D403/12
- IPC: C07D403/12 ; A61K31/404 ; C07D209/30 ; A61K31/4155

Abstract:
Provided is a compound having formula (I): wherein R2 is selected from —C1, —Br and —CN; R1 and R4 are independently selected from H and —F; R631, R632, R641 and R642 are independently selected from —H, —F and substituted or unsubstituted C1-C3 alkyl groups; and R651 and R652 are independently selected from H and substituted or unsubstituted C1-C3 alkyl groups and substituted or unsubstituted phenyl groups; and wherein at least one of R631, R632, R641, R642 and R652 is not —H, or wherein when all of R631, R632, R641, R642 and R652 are —H, R651 is not Me or Et.
Public/Granted literature
- US20180258075A1 Pharmaceutical Compound Public/Granted day:2018-09-13
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